مقایسه سطح سرمی سرلوپلاسمین مادر در حاملگی های طبیعی و پره اکلامپتیک

Introduction & Objective: Preeclampsia is a pregnancy disorder that is associated with increased maternal and perinatal mortality. Imbalance between lipid radicals and antioxidant system is discussed as one of the possible mechanisms of pathogenesis of preeclampsia. The purpose of this study was to evaluate serum ceruloplasmin level and to examine its relationship with severity and complications of preeclampsia. Materials & Methods: Thiscase - control studywas performed on30pregnant womendiagnosed withpreeclampsia in HamedanFatemiyeh Hospital as the case group. 30 womenwithnormalpregnancy, aftermatching, as controlsentered into the study. Aftermeasuringserumceruloplasmin level, complicationssuch asheadache, visual disturbances, intrauterine growth restriction, oligohydramnios, weight loss and placenta decolmantwere recordedin thecheck listsdesigned foreach patient. Data was analyzedthrough SPSS softwareversion 16, chi-square andttests. Results: Meanserumceruloplasmin level in the case group was 317.01mg/dl andin the control group was197.94mg/dl. Thedifference between them wasstatistically significant. Also headacheandvisual disturbances in the case groupweresignificantlyhigher than the control group. Conclusion: The resultsshowed thatserum ceruloplasmin level in the patients with preeclampsia is higher than those with normal pregnancy.